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Invitrogen
Human GATSL2 (aa 304-329) Control Fragment Recombinant Protein
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产品信息
RP-104512
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
FDHALVPEENINGVISALKVSQAEKH
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (88%), Rat (88%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63416. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cellular arginine sensor for mTORC1 protein 2; Cytosolic arginine sensor for mTORC1 subunit 2; GATL2; GATS protein-like 1; GATS protein-like 2; GATS-like protein 1; GATS-like protein 2
基因别名: CASTOR2; GATSL1; GATSL2
UniProt ID: (Human) A6NHX0
Entrez Gene ID: (Human) 729438
