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Invitrogen
Human Glucocorticoid Receptor Recombinant Protein
产品信息
A15663
产品规格
种属
Human
Expression System
Baculovirus
分子量
85.7 kDa
分类
Recombinant
类型
Protein
纯度
Partially purified to retain activity.
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Glucocorticoid receptor recombinant protein is an insect cell-expressed, full-length, untagged, human nuclear hormone receptor that is partially purified in order to maintain high ligand binding activity. Further purification results in decreased activity, presumably due to loss of endogenous accessory proteins.
GR human recombinant protein is:
• Flexible-use in your in-house assay or as part of our PolarScreen™ Glucocorticoid Receptor Competitor assays for a complete assay solution
• Ready to use-active and native (untagged)
• Convenient-available in bulk sizes
Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond.
Used in:
PolarScreen™ Glucocorticoid Receptor Competitor Assay, Red
PolarScreen™ Glucocorticoid Receptor Competitor Assay, Green
Protein Form: Recombinant, Full Length
靶标信息
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; gr alpha; GR Kit; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858
基因别名: GCCR; GCR; GCRST; GR; GRL; NR3C1
UniProt ID: (Human) P04150
Entrez Gene ID: (Human) 2908
