PEP-002 is a 15 amino acid (amino acids 245-259) synthetic peptide whose sequence is from the amino terminus of the human glucocorticoid receptor (GR). The sequence of this peptide is (amino to carboxy terminus): C-K-P-L-I-L-P-D-T-K-P-K-I-K-D (The N-terminal cysteine has been added to facilitate conjugation and is not a part of the native human GR sequence)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human GR, catalog # PA1-512. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance.
蛋白别名: glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; gr alpha; GR Kit; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858
基因别名: GCCR; GCR; GCRST; GR; GRL; NR3C1
UniProt ID: (Human) P04150
Entrez Gene ID: (Human) 2908