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Invitrogen
Human MAP3K9 (MLK1), GST Tag Recombinant Protein
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产品信息
PR7007A
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
1-500
标签
GST-tag
分子量
83.4 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris, pH 7.5, with 2mM DTT, 50% glycerol, 0.02% Triton X-100, 0.5mM EDTA, 150mM NaCl
内含物
no preservative
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Catalytic
靶标信息
MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity)
基因别名: MAP3K9; MEKK9; MLK1; PRKE1
UniProt ID: (Human) P80192
Entrez Gene ID: (Human) 4293
