This peptide corresponds to 28 amino acids near the center of human NPAS3
PEP-0485 can be used as a blocking peptide with polyclonal antibody PA5-20365.
Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
蛋白别名: Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; Member of PAS protein 6; Neuronal PAS domain-containing protein 3; Neuronal PAS3; PAS domain-containing protein 6
基因别名: BHLHE12; MOP6; NPAS3; PASD6
UniProt ID: (Human) Q8IXF0
Entrez Gene ID: (Human) 64067