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Invitrogen
Human PGRMC2 Control Fragment Recombinant Protein
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产品信息
RP-95669
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
RWRAVMAAGDGDVKLGTLGSGSESSNDGGSESPCDA
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (53%), Rat (53%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-59465. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Membrane-associated progesterone receptor component 2; progesterone membrane binding protein; Progesterone membrane-binding protein; Steroid receptor protein DG6
基因别名: DG6; PGRMC2; PMBP
UniProt ID: (Human) O15173
Entrez Gene ID: (Human) 10424
