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Invitrogen
Human PIK3CA E542K/PIK3R1 (p110 alpha E542K/p85 alpha), His Tag Recombinant Protein
产品信息
A33738
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
Full length
标签
His-tag
分子量
125.4-84.7 kDa
分类
Recombinant
类型
Protein
偶联物
Unconjugated
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM sodium phosphate, pH 7, with 300mM NaCl, 0.25mM DTT, 0.1mM PMSF, 150mM Imidazole, 25% glycerol
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This PIK3CA E542K/PIK3R1 (p110 alpha E542K/p85 alpha) recombinant human protein (full length) was expressed in insect cells.
PIK3CA E542K/PIK3R1 (p110 alpha E542K/p85 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Full Length, Recombinant, Active, Mutant
靶标信息
PIK3CA E542K/PIK3R1 (p110 alpha E542K/p85 alpha) lipid kinase is comprised of a 110 kDa catalytic subunit and an 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. PIK3CA is frequently mutated or amplified in a variety of cancers including ovarian and colon and this kinase is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of PIK3CA is essential for vascular development and inactivation of PIK3CA leads to severe defects in angiogenic sprouting and vascular remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p110 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PIK3CA; PIK3R1; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA
基因别名: AGM7; CLOVE; CWS5; GRB1; IMD36; MCAP; MCM; MCMTC; p110-alpha; p85; p85-ALPHA; PI3K; PI3K-alpha; PIK3CA; PIK3R1
UniProt ID: (Human) P42336, (Human) P27986
Entrez Gene ID: (Human) 5290, (Human) 5295
