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Invitrogen
Human PLEKHG6 Control Fragment Recombinant Protein
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产品信息
RP-106834
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
KAFGPPHEGPLQGLVASRIETYGGRHRASAQSTTGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKR
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (77%), Rat (77%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66151. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; Myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6
基因别名: MyoGEF; PLEKHG6
UniProt ID: (Human) Q3KR16
Entrez Gene ID: (Human) 55200
