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Invitrogen
Human RAD51 Recombinant Protein
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产品信息
RP-4964
产品规格
Expression System
E. coli
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
1 mg/mL
Amount
20 µg
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
RP-4964 has been successfully used in Western blot proceedures. It is specific for the ~35 kDa Rad51 protein.
The Human gene Rad51 is homologous to the highly conserved bacterial gene RecA.
RP-4964 is highly purified from E. coli over-expressing human Rad51 protein as a recombinant protein. The tag was removed from the recombinant protein (though it still contains Gly-Ser-His at the N-terminal). The protein has been shown to retain nuclear filament forming and strand-exchange activity as well as interaction with Rad52. RP-4964 was confirmed to possess single strand DNA stimulated ATPase activity.
靶标信息
RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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