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Invitrogen
Human RGL4 Control Fragment Recombinant Protein
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产品信息
RP-91551
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
KLLTNLPAAAVLSAQVYSAVLRGLWEENVCGTPGRTRVCTALLYGQVCPFQDSTDGLRTITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGLEDHQEIVLGQLVLPEPNEAKPDDPAPRPGQHAL
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (20%), Rat (20%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57492. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4) is a gene that encodes a member of the RalGDS family, which is involved in the regulation of the Ras signaling pathway. This gene is located on chromosome 22 and is highly expressed in various tissues, including the brain and reproductive organs. RGL4 is known to interact with RalA and RalB, small GTPases that play crucial roles in cellular processes such as vesicular trafficking, cytoskeleton dynamics, and cell proliferation. Studies have shown that the expression of RGL4 has significant implications in various cancers. For instance, low expression of RGL4 is associated with poor prognosis and increased immune infiltration in lung adenocarcinoma (LUAD). Conversely, overexpression of RGL4 has been correlated with resistance to Midostaurin in FLT3-ITD mutant acute myeloid leukemia (AML) samples. These findings highlight the gene's potential as a biomarker for prognosis and therapy response in certain cancers, making it a valuable target for further research and clinical applications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hRGR; Ral guanine nucleotide dissociation stimulator-like 4; Ral-GDS related protein Rgr; Ral-GDS-related protein; RalGDS related oncogene; RalGDS-like 4
基因别名: RGL4; RGR
UniProt ID: (Human) Q8IZJ4
Entrez Gene ID: (Human) 266747
