This peptide corresponds to 15 amino acids near the center of human Rkhd1.
PEP-0741 can be used as a blocking peptide with polyclonal antibody PA5-20621.
Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3’-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
蛋白别名: bcl-2 ARE RNA binding protein; ring finger (C3HC4 type) and KH domain containing 1; ring finger and KH domain containing 1; RING finger and KH domain-containing protein 1; RING finger protein 193; RNA-binding protein MEX3D; TINO
基因别名: KIAA2031; MEX-3D; MEX3; MEX3D; OK/SW-cl.4; RKHD1; RNF193; TINO
UniProt ID: (Human) Q86XN8
Entrez Gene ID: (Human) 399664