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Invitrogen
Human SNX2 (aa 77-149) Control Fragment Recombinant Protein
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产品信息
RP-96984
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
ATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDP
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (96%), Rat (96%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83367. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTB-36H16.2; MGC5204; Sorting nexin-2; Transformation-related gene 9 protein; TRG-9
基因别名: SNX2; TRG-9; TRG9
UniProt ID: (Human) O60749
Entrez Gene ID: (Human) 6643
