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Invitrogen
Human nNOS (aa 1411-1425) Synthetic Peptide
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产品信息
PEP-190
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-190 is a 16 amino acid synthetic peptide whose sequence corresponds to amino acid residues 1411-1425 from human nNOS. The sequence of PEP-190 is (amino to carboxy terminus) is C N (1411) R L R S E S I A F I E E S K (1425). This sequence is 100% conserved in rat, mouse, frog, and rabbit nNos protiens.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat nNOS, catalog # PA1-033. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
靶标信息
NOS activity requires homodimerization as well as three cosubstrates (L-arginine, NADPH and O2) and five cofactors or prosthetic groups (FAD, FMN, calmodulin, tetrahydrobiopterin and heme). Several distinct NOS isoforms have been described and been shown to represent the products of three distinct genes. These include two constitutive Ca2+/CaM-dependent forms of NOS, including NOS1 (also designated ncNOS) whose activity was first identified in neurons, and NOS3 (also designated ecNOS), first identified in endothelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bNOS; bNOS1; Brain NOS; Constitutive NOS; N-NOS; NC-NOS; Neuronal NOS; Nitric oxide synthase 1; nitric oxide synthase 1 (neuronal); Nitric oxide synthase, brain; NOS Type 1; NOS type I; Peptidyl-cysteine S-nitrosylase NOS1; Phospho-bNOS; Phospho-Brain NOS
基因别名: bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS; NOS1
UniProt ID: (Human) P29475
Entrez Gene ID: (Human) 4842
