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Invitrogen
Mouse PER1 (aa 39-51) Synthetic Peptide
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产品信息
PEP-076
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-076 is a 14 amino acid synthetic peptide whose sequence corresponds to residues 39-51 of mouse PER1 with a carboxy terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): P39-S-L-A-D-D-T-D-A-N-S-N-G51-C
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PER1, catalog # PA1-524. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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