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Invitrogen
Mouse PPAR alpha (aa 1-18) Synthetic Peptide
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产品信息
PEP-025
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-025 is an 18 amino acid (amino acids 1-18) synthetic peptide whose sequence is derived from murine PPARa and is completely unique to PPARa. A COOH-terminal cysteine residue was added for conjugation to KLH. The sequence of this peptide is (amino to carboxy terminus): M1-V-D-T-E-S-P-I-C-P-L-S-P-L-E-A-D-D18-C
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and PPARa, catalog # PA1-822A. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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