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Invitrogen
Mouse RARA (aa 444-462) Synthetic Peptide
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产品信息
PEP-004
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-004 is a synthetic peptide whose sequence is from the C-terminal end of mouse retinoic acid receptor alpha (RAR alpha). The 19 amino acid sequence extends from amino acids 444 to 462 of RAR alpha. The sequence of PEP-004 is (amino to carboxy terminus): C-S-P-S-L-S-P-S-S-H-R-S-S-P-A-T-Q-S-P
This peptide may be used for neutralization and control experiments with the monoclonal and polyclonal antibodies that react with this product and human and mouse RAR*, catalog # MA1-810A and PA1-810A. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
靶标信息
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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