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产品信息
PEP-0176
产品规格
种属反应
Mouse
宿主/亚型
Artificial Control
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 16 amino acids from the middle of mouse TLR11.
PEP-0176 can be used as a blocking peptide with polyclonal antibody PA5-20057.
靶标信息
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Gm1365; RP23-392K10.4; Toll-like receptor 11; Toll-like receptor 12
基因别名: Gm287; Tlr11; Tlr12
UniProt ID: (Mouse) Q6R5P0
Entrez Gene ID: (Mouse) 239081
