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Gibco
PeproGMP® Human BMP-4 Recombinant Protein, PeproTech®
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PeproGMP® Human BMP-4 Protein (GMP120-05ET-50UG) in Bioactivity
Bioassay of PeproGMP® Human BMP-4 Recombinant Protein, PeproTech (Product # GMP120-05ET-50UG) compared to Human BMP-4, Animal-Free Recombinant Protein, PeproTech (Product # AF-120-05ET-01M), demonstrating comparable bioactivity across product grades.
产品信息
GMP120-05ET-50UG
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
MKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR
分子量
24.2 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
≤0.1 EU/µg
活性
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient
产品详细信息
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. PeproTech's E. coli-derived Human BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full-length BMP-4 precursor, as well as an N-terminal methionine. PeproTech Recombinant Human BMP-4 is a 24.2 kDa protein.
PeproGMP BMP-4 can be used with PeproGMP VEGF-165 and PeproGMP SCF in CTS StemScale medium for pluripotent stem cell differentiation, specifically for mesoderm and hematopoetic progenitor cell induction.
Reconstitute using 5mM HCl, pH 3.0 to a concentration of 0.1-1.0 mg/ml.
Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis.
All PeproGMP® products are manufactured using animal-derived component free materials.
Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.
靶标信息
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.
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生物信息学
蛋白别名: BMP; BMP-2B; BMP-4; Bone morphogenetic protein; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein
基因别名: BMP2B; BMP2B1; BMP4; DVR4; MCOPS6; OFC11; ZYME
UniProt ID: (Human) P12644
Entrez Gene ID: (Human) 652
