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Gibco
PeproGMP® Human Heregulin beta-1 Recombinant Protein, PeproTech®
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PeproGMP® Human Heregulin beta-1 Protein (GMP100-03-50UG) in Bioactivity
Cell proliferation assay analysis of PeproGMP® Human Heregulin beta-1 Recombinant Protein, PeproTech (Product # GMP100-03-50UG) compared to Human Heregulin beta-1, Animal-Free Recombinant Protein, PeproTech (Product # AF-100-03-1MG), demonstrating comparable bioactivity across product grades.
产品信息
GMP100-03-50UG
应用
建议稀释比
已发表文章
产品规格
种属
Human
已发表种属
Human
Expression System
E. coli
氨基酸序列
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
分子量
7.5 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
≤0.1 EU/µg
活性
Determined by proliferation of human MCF-7 cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient
产品详细信息
The neuregulin/heregulin protein is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). The PeproTech Recombinant Human Heregulin beta-1 (HRG1-beta1 is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin beta-1 (65 amino acid residues).
Reconstitute using sterile water (i.e., WFI) to a concentration of 0.1-1.0 mg/ml.
Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis.
All PeproGMP® products are manufactured using animal-derived component free materials.
Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.
靶标信息
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.
生物信息学
蛋白别名: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor
基因别名: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297
Entrez Gene ID: (Human) 3084
