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Gibco
PeproGMP® Human IL-2 Recombinant Protein, PeproTech®
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PeproGMP® Human IL-2 Protein (GMP200-02-50UG) in Bioactivity
Cell proliferation assay analysis of PeproGMP® Human IL-2 Recombinant Protein, PeproTech (Product # GMP200-02-50UG) compared to Human IL-2, Animal-Free Recombinant Protein, PeproTech (Product # AF-200-02-1MG), demonstrating comparable bioactivity across product grades.
产品信息
GMP200-02-50UG
应用
建议稀释比
已发表文章
产品规格
种属
Human
已发表种属
Human,
Mouse
Expression System
E. coli
氨基酸序列
MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT
分子量
15.5 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
≤0.1 EU/µg
活性
Determined by the proliferation of mouse CTLL-2 cells. PeproGMP Recombinant Human IL-2 has been tested against the WHO standard NIBSC 86/500. Find the International Unit (IU) value here.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient
产品详细信息
PeproTech Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfe bond.
PeproGMP IL-2 is commonly used in ex vivo cell therapy for the expansion of T and NK immune cell cultures.
Reconstitute using sterile 100mM Acetic Acid to a concentration of 0.1-1.0 mg/ml.
Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis.
All PeproGMP® products are manufactured using animal-derived component free materials.
Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.
靶标信息
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.
生物信息学
蛋白别名: aldesleukin; H-IL-2; il 2; IL-2; ILN; Interleukin; Interleukin-2; Interleukin2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; M-IL-2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
基因别名: IL-2; IL2; lymphokine; TCGF
UniProt ID: (Human) P60568
Entrez Gene ID: (Human) 3558
