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Invitrogen
Rat RPH3A (aa 1-18) Synthetic Peptide
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产品信息
PEP-102
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-102 is a 18 amino acid synthetic peptide whose sequence corresponds to amino acid residues 1-18 of rat rabphilin 3A. The sequence of this peptide is (amino to carboxy terminus): M (1)-T-D-T-V-V-N-R-W-M-Y-P-G-D-G-P-L-Q (18)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat rabphilin 3A, catalog # PA1-774. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B, and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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