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Invitrogen
beta-2 Adaptin Synthetic Peptide
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产品信息
PEP-293
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
1 mg/mL
规格
50 µg
保存条件
-20°C
运输条件
Wet ice
产品详细信息
This peptide corresponds to amino acids I(588) HRKHLPIHHGSTDAGDSP (606) of human beta Adaptin 2 and can be used as a blocking peptide with polyclonal antibody PA1-1066. This sequence is identical in human, mouse, rat and bovine.
靶标信息
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ~100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ~50 and ~17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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