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Invitrogen
Human CD42b/GPIb-alpha ELISA Kit
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产品规格
检测灵敏度
0.21 ng/mL
测定范围
0.21-50 ng/mL
检测样本类型/体积
{Serum=50 µL, Plasma=50 µL, Supernatant=50 µL}
手工操作时间
1 hr 20 min
总时间
4 hr 45 min
均相（无需洗涤）
No
批间差异
<12%
批内差异
<10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
运输条件
Wet ice
储存
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
蛋白名称
CD42b
均相（无需洗涤）
Human
检测试剂盒格式
Sandwich ELISA Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
Human CD42b/GPIb-alpha quantitates human CD42b/GPIb-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD42b/GPIb-alpha.
靶标信息
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GP1BA, GPIbA, GPIbalpha, VWDP
基因ID : (Human) 2811
基因符号 : GP1BA
蛋白别名 : Antigen CD42b-alpha, CD42a, GPIB, GPIb alpha, GPIX, GP-IX, MGC34595, Platelet GPIX, CD42b, glycoprotein Ib (platelet), alpha polypeptide, GP-Ib alpha, mutant platelet membrane glycoprotein Ib-alpha, Platelet glycoprotein Ib alpha chain, platelet membrane glycoprotein 1b-alpha subunit, platelet membrane glycoprotein Ib-alpha
UniProt ID (Human) P07359
