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Human Cathepsin A/CTSA quantitates human Cathepsin A/CTSA in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cathepsin A/CTSA.
The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : BSVD6, GLB2, GSL, NGBE, PPCA, PPGB
基因ID : (Human) 5476
基因符号 : CTSA
蛋白别名 : beta-galactosidase 2, beta-galactosidase protective protein, carboxypeptidase C, carboxypeptidase Y-like kininase, carboxypeptidase-L, deamidase, lysosomal carboxypeptidase A, protective protein cathepsin A, protective protein precursor, unnamed protein product, urinary kininase
UniProt ID (Human) P10619