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Human Cathepsin C quantitates human Cathepsin C in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cathepsin C.
Cathepsin C, known also as dipeptidyl aminopeptidase I (DPPI), is a tetrameric lysosomal cysteine peptidase belonging to the papain family. Cathepsin C is involved in intracellular protein degradation and the processing of protein precursors, where it participates in cell growth, neuraminidase activation, and platelet factor XIII activation. Cathepsin C is largely related to other lysosomal cysteine proteinases, including cathepsin B, H and L. Enzymatically, Cathepsin C is capable of sequentially removing dipeptides from the amino terminus, and it requires halide ions, namely chloride ions, and thiols for complete enzymatic activity. Protein levels of Cathepsin C are detected in a variety of tissues, and it is most highly expressed in spleen, kidney, cytotoxic lymphocytes and myeloid cells, where it localizes to the secretory granule compartment. Cathepsin C is initially synthesized as a proenzyme that is rapidly processed to generate two distinct chains that function together as the mature form of the enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CPPI, CTSC, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS
基因ID : (Human) 1075
基因符号 : CTSC
蛋白别名 : Cathepsin C, Cathepsin J, Dipeptidyl peptidase 1, Dipeptidyl peptidase I, Dipeptidyl transferase, dipeptidyl-peptidase, dipeptidyl-peptidase I, DPP-I
UniProt ID (Human) P53634