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Human Coagulation Factor VII quantitates human Coagulation Factor VII in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Coagulation Factor VII.
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : F7, SPCA
基因ID : (Human) 2155
基因符号 : F7
蛋白别名 : Coagulation factor VII, coagulation factor VII (serum prothrombin conversion accelerator), eptacog alfa, Factor 7, Factor7, FVII coagulation protein, Proconvertin, Serum prothrombin conversion accelerator, SPCA
UniProt ID (Human) P08709