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Human FOLR3 quantitates human FOLR3 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human FOLR3.
Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, alpha, beta, gamma, gamma' (which is produced by alternative splicing) and delta. beta-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. gamma-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of delta-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The alpha isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : FOLR3, FR-G, FR-gamma, gamma-hFR
基因ID : (Human) 2352
基因符号 : FOLR3
蛋白别名 : Folate receptor 3, folate receptor 3 (gamma), Folate receptor gamma, FR gamma, FR- gamma, FR-gamma
UniProt ID (Human) P41439