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Invitrogen
Human Holo TC ELISA Kit
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产品规格
检测灵敏度
0.00489 pmol/mL
测定范围
0.00781-0.5
检测样本类型/体积
{Plasma=50 µL, Serum=50 µL}
手工操作时间
1 hr 20 min
总时间
2 hr 30 min
均相（无需洗涤）
No
批间差异
<10%
批内差异
<10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Standard and Sample Diluent
Biotinylated Detection Antibody Diluent
HRP Conjugate Diluent
Wash Buffer Concentrate
Stop Solution
Substrate Solutio
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Standard and Sample Diluent
Biotinylated Detection Antibody Diluent
HRP Conjugate Diluent
Wash Buffer Concentrate
Stop Solution
Substrate Solutio
Adhesive Plate Covers
运输条件
Wet ice
储存
At 2-8°C for one year. Protect from light. Do not freeze.
蛋白名称
Holotranscobalamin
均相（无需洗涤）
All
检测试剂盒格式
Competitive ELISA
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
The HoloTC (Holotranscobalamin) ELISA quantitates HoloTC in serum, plasma, and other biological fluids
靶标信息
Holotranscobalamin (holoTC) is a complex of vitamin B12 and the protein transcobalamin, which is essential for transporting vitamin B12 into cells. It binds to the receptor CD320, facilitating the transport of vitamin B12 across cell membranes, where vitamin B12 functions as a coenzyme for critical enzymatic reactions. Transcobalamin, also known as transcobalamin II, is a beta-globulin protein synthesized by ileal enterocytes, endothelial cells, macrophages, and hepatocytes, which transports newly absorbed vitamin B12 from the intestines to the liver and other body organs via receptor-mediated endocytosis. Genetic polymorphisms in the transcobalamin gene (TCN2), such as TCN2 776C->G and TCN2 67A->G, can influence the levels of holotranscobalamin in the serum, thus impacting overall vitamin B12 status in individuals. The holoTC level is often used as a biomarker for assessing vitamin B12 deficiency, which is critical for diagnosing conditions related to inadequate vitamin B12 absorption or metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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