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The Human ICAM-1 Rapid ELISA Kit quantitates ICAM-1 (CD54) in serum and plasma
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : BB2, CD54, ICAM1, P3.58
基因ID : (Human) 3383
基因符号 : ICAM1
蛋白别名 : CD54, cell surface glycoprotein P3.58, epididymis secretory sperm binding protein, Human rhinovirus receptor, Ly 47, MALA2, sCD54, soluble CD54, Surface antigen of activated B cells, ICAM-1, ICAM-1 soluble variant, Intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, intercellular adhesion molecule-1 precursor, Major group rhinovirus receptor, major group rhinovirus receptor precusor, unnamed protein product
UniProt ID (Human) P05362