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Human IL-17RC quantitates human IL-17RC in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-17RC.
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CANDF9, IL17-RL, IL17RC, IL17RL, UNQ6118/PRO20040/PRO38901
基因ID : (Human) 84818
基因符号 : IL17RC
蛋白别名 : IL-17 receptor C, IL-17RL, IL17F receptor, IL17Rhom, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14
UniProt ID (Human) Q8NAC3