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Human IL-21 R quantitates human IL-21 R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-21 R.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CD360, IL21R, NILR, UNQ3121/PRO10273
基因ID : (Human) 50615
基因符号 : IL21R
蛋白别名 : CD360, IL-21 receptor, Interleukin-21 receptor, MGC10967, Novel interleukin receptor
UniProt ID (Human) Q9HBE5