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Human LTF/Lactoferrin quantitates human LTF/Lactoferrin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human LTF/Lactoferrin.
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : GIG12, HEL110, HLF2, LF
基因ID : (Human) 4057
基因符号 : LTF
蛋白别名 : CKRX, Kaliocin 1, Kaliocin1, Lactoferricin H, LactoferroxinA, LactoferroxinB, LactoferroxinC, Lfcin H, LfcinH, epididymis luminal protein 110, growth-inhibiting protein 12, HLF, HLF2, iron binding protein, transferrin family member, iron transfer protein, kaliocin-1, lactoferricin, lactoferroxin, lactotransferrin, neutrophil lactoferrin, talalactoferrin, unnamed protein product
UniProt ID (Human) P02788