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The Human Lung Resistance-Related Protein (LRP) ELISA quantitates LRP in serum, plasma, and other biological fluids
The Human Lung Resistance-Related Protein (LRP) solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the binding of the second (detector) antibody to the target on a different epitope from the capture antibody. An antibody conjugated with enzyme binds the formed sandwich. After incubation and washing steps to rid the microplate of unbound substances, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.
Rigorous validation:
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : LRP, MVP, VAULT1
基因ID : (Human) 9961
基因符号 : MVP
蛋白别名 : Lung resistance-related protein, Major vault protein, MVP, MVP1, Testicular Secretory Protein Li 30, VAULT1, vRNP, testicular secretory protein Li 30
UniProt ID (Human) Q14764