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Human Noggin ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of human Noggin in serum, plasma, and cell culture supernatants.
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : SYM1, SYNS1, SYNS1A
基因ID : (Human) 9241
基因符号 : NOG
蛋白别名 : Noggin precursor, symphalangism 1 (proximal), unnamed protein product
UniProt ID (Human) Q13253