Search
Search
Invitrogen
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Human PCSK2 quantitates human PCSK2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human PCSK2.
The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : NEC 2, NEC-2, NEC2, PC2, PCSK2, SPC2
基因ID : (Human) 5126
基因符号 : PCSK2
蛋白别名 : EC 3.4.21.94, KEX2-like endoprotease 2, NEC 2, Neuroendocrine convertase 2, PC2, Prohormone convertase 2, Proprotein convertase 2
UniProt ID (Human) P16519