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The Human PLAP/ALPP Rapid ELISA Kit quantitates Placental Alkaline Phosphatase in serum and plasma
Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : ALP, ALPI, ALPP, IAP, PALP, PLAP, PLAP-1
基因ID : (Human) 250
基因符号 : ALPP
蛋白别名 : Alkaline phosphatase placental type, Alp1, AP-TNAP, DOA1, FLJ11281, FLJ40094, Regan isozyme, TNAP, TNSALP, nagao Isozyme, P PLAP, PLA2P, PLAA, placental heat-stable alkaline phosphatase, PLAP1, FLJ61142, FLJ93059, Germ-cell alkaline phosphatase, HOPS, MGC161443, MGC167935, Alkaline phosphatase Regan isozyme, Alkaline phosphatase, placental type, alkaline phosphomonoesterase, glycerophosphatase, Intestinal alkaline phosphatase, Intestinal-type alkaline phosphatase, Placental alkaline phosphatase 1, placental alkaline phosphatase precursor, PLAP-1, preplacental alkaline phosphatase (EC 3.1.3.1), preplacental alkaline phosphatase type 1 (EC 3.1.3.1), unnamed protein product
UniProt ID (Human) P05187