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Human Semaphorin 4D quantitates human Semaphorin 4D in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Semaphorin 4D.
Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : C9orf164, CD100, coll-4, M-sema-G, SEMA4D, SEMAJ
基因ID : (Human) 10507
基因符号 : SEMA4D
蛋白别名 : A8, BB18, CD100, GR3, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D, 4D, Semaphorin-4D
UniProt ID (Human) Q92854