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Human Sortilin quantitates human Sortilin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Sortilin.
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : Gp95, LDLCQ6, NT3, NTR3, SORT1
基因ID : (Human) 6272
基因符号 : SORT1
蛋白别名 : 100 kDa NT receptor, Glycoprotein 95, Gp95, Neurotensin receptor 3, NT3, Sortilin
UniProt ID (Human) Q99523