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Invitrogen
Mouse CD48 Rapid ELISA Kit
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产品规格
检测灵敏度
9.38 pg/mL
测定范围
15.63-1000
检测样本类型/体积
{Serum=50 µL, Plasma=50 µL}
手工操作时间
15 min
总时间
1 hr 30 min
均相（无需洗涤）
No
批间差异
<10%
批内差异
<10%
检测仪器
Absorbance Microplate Reader
产品规格
96 Tests
产品成分
Pre-coated 96 well plate, Standard, HRP Conjugate, Standard & Sample Diluent, HRP Conjugate Diluent, Wash Buffer, TMB Substrate, Stop Solution, Plate Sealer
运输条件
Wet ice
储存
Refer to product documentation for component specific storage temperature.
蛋白名称
CD48
均相（无需洗涤）
Mouse
检测试剂盒格式
Rapid ELISA Kit
检测抗体结合物
HRP
标签或染料
Unconjugated
关于本试剂盒
The Mouse CD48 Rapid ELISA Kit quantitates CD48 in serum and plasma
靶标信息
CD48, also known as Blast-1, is a 45 kDa glycoprotein that is part of the SLAM and Ig superfamilies. It is a GPI-anchored protein broadly expressed on most hematopoietic cells, including lymphocytes and monocytes, but is weakly expressed on granulocytes and absent on platelets, fibroblasts, epithelium, and endothelium. CD48 plays a critical role in adhesion and T cell activation, serving as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2. The interaction between 2B4 and CD48 among NK and NK-T cells regulates cell proliferation. CD48 is involved in eosinophil activation and its expression increases in several infectious diseases. It is also a marker for detecting defects in the GPI anchoring structure in patients with paroxysmal nocturnal hemoglobulinuria (PNH). Recent studies have highlighted the differential expression of SLAM family members, including CD48, CD150, and CD244, among bone marrow hematopoietic progenitors. This provides a useful tool for predicting the primitiveness of hematopoietic progenitors: hematopoietic stem cells (HSCs) are CD150(+)CD244(-)CD48(-), non-self-renewing multipotent progenitors (MPPs) are CD244(+)CD150(-)CD48(-), and the most restricted progenitors are CD48(+)CD244(+)CD150(-). Additionally, the 2B4-CD48 interaction may be involved in the pathology of allergic airway diseases, offering a potential pharmacological target for treating conditions like allergic rhinitis and asthma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
基因别名 : AI449234, AW610730, Bcm-1, BCM1, BLAST, BLAST-1, BLAST1, Cd48, MEM-102, Sgp-60, SLAMF2
基因ID : (Mouse) 12506
基因符号 : Cd48
蛋白别名 : B-cell activation marker, CD48 antigen (B cell membrane protein), CD48d, sCD 48, sCD48, Signaling lymphocytic activation molecule 2 (SLAMF2), soluble CD 48, soluble CD48, BCM1 surface antigen, BLAST-1, CD48, CD48 antigen, HM48-1, MRC OX-45 surface antigen, sgp-60, Signaling lymphocytic activation molecule 2, SLAM family member 2, SLAMF2
UniProt ID (Mouse) P18181
