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Mouse CD74 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of mouse CD74 in cell culture supernatants, plasma, and serum samples.
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : Cd74, CLIP, DHLAG, HLADG, Ia-GAMMA, Ii
基因ID : (Mouse) 16149
基因符号 : Cd74
蛋白别名 : CD74, CD74 antigen, class II-associated invariant chain peptide, dinucleotide microsatellite, H-2 class II histocompatibility antigen gamma chain, histocompatibility: class II antigens, gamma chain of, HLA-DR-GAMMA, Ia antigen-associated invariant chain, Ia-associated invariant chain, Ii, invariant polypeptide of major histocompatibility complex, class II antigen-associated, MHC class II-associated invariant chain
UniProt ID (Mouse) P04441