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Mouse DLL4 quantitates mouse DLL4 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse DLL4.
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : Delta4, Dll4
基因ID : (Mouse) 54485
基因符号 : Dll4
蛋白别名 : Delta-like protein 4, Delta4, Drosophila Delta homolog 4, MGC126344
UniProt ID (Mouse) Q9JI71