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Mouse HGFR/MET quantitates mouse HGFR/MET in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse HGFR/MET.
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : AI838057, c-Met, HGF, HGFR, Par4
基因ID : (Mouse) 17295
基因符号 : Met
蛋白别名 : cMet, EC 2.7.10.1, HGF-SF receptor, oncogene MET, sc MET, soluble c met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, met proto-oncogene tyrosine kinase, proto-oncogene c-Met, scatter factor receptor, SF receptor, tyrosine-protein kinase Met