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Mouse LIGHT ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of mouse LIGHT (TNFSF14) in serum, plasma, and cell culture supernatants.
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : HVEM-L, HVEML, LIGHT, LTg, Ly113, Tnlg1d
基因ID : (Mouse) 50930
基因符号 : Tnfsf14
蛋白别名 : LIGHT, sCD258, sLIGHT, soluble CD258, soluble LIGHT, TR2, tumor necrosis factor ligand 1d, type II transmembrane protein
UniProt ID (Mouse) Q9QYH9