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产品规格
检测灵敏度
Lot-specific
测定范围
Lot-specific
手工操作时间
1 hr 45 min
总时间
24 hr 30 min
均相（无需洗涤）
No
检测仪器
Absorbance Microplate Reader
产品规格
10 x 96 Tests
产品成分
This Mouse RANKL (RANK Ligand) ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately.
储存
Refer to product documentation for component specific storage temperature.
蛋白名称
RANKL (RANK Ligand)
蛋白家族
Growth Factors & Receptors
均相（无需洗涤）
Mouse
检测试剂盒格式
ELISA Development Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
900-K233K consists of: 900-K233 (capture antibody, detection antibody, and protein standard), and AVIDIN-60UL (avidin HRP-conjugate).
Mouse RANKL (RANK Ligand) ABTS ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant mouse RANKL (RANK Ligand) in a sandwich ELISA format. Mouse RANKL (RANK Ligand) ABTS ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells.
The ABTS ELISA Buffer Kit (Product # 900-K00), sold separately, is recommended to be used in conjunction with this ABTS ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
靶标信息
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
基因别名 : Ly109l, ODF, OPG, OPGL, RANKL, Tnfsf11, Trance
基因ID : (Mouse) 21943
基因符号 : Tnfsf11
蛋白别名 : CD254, H-RANK-L, M-Rank-L, rank-l, RP11-86N24.2, srankl, ODF, OPG ligand, OPGL, Osteoclast differentiation factor, Osteoprotegerin ligand, RANKL, receptor activator of NF-kappaB ligand, receptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, Tumor necrosis factor ligand superfamily member 11, tumor necrosis factor-related activation-induced cytokine
UniProt ID (Mouse) O35235
