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The Mouse TCK-1 (PPBP) Rapid ELISA Kit quantitates PPBP in serum and plasma
Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a-chemokine family, resides in the a-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : 2400003M24Rik, AI854500, b-TG1, beta-TG, CTAP3, CTAPIII, Cxcl7, LA-PF4, LDGF, MDGF, NAP-2, NAP-2-L1, Scyb7, TGB, TGB1, THBGB1
基因ID : (Mouse) 57349
基因符号 : Ppbp
蛋白别名 : chemokine (C-X-C motif) ligand 7, platelet basic protein