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Mouse TGM2 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of mouse Transglutaminase 2/TGM2 in cell culture supernatants, plasma, and serum samples.
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : G[a]h, TG2, TGase2, tTG, tTGas
基因ID : (Mouse) 21817
基因符号 : Tgm2
蛋白别名 : C polypeptide, G alpha h, G-ALPHA-h, GNAH, RP5-1054A22.2, TGase-H, Tissue type transglutaminase, Transglutaminase 2 C polypeptide, G-protein/transglutaminase, isopeptidase TGM2, protein-glutamine deamidase TGM2, protein-glutamine dopaminyltransferase TGM2, protein-glutamine histaminyltransferase TGM2, protein-glutamine noradrenalinyltransferase TGM2, protein-glutamine serotonyltransferase TGM2, protein-glutamine-gamma-glutamyltransferase, TG(C), TGase C, TGase II, TGase-2, TGC, tissue transglutaminase, transglutaminase C, transglutaminase II, transglutaminase-2, unnamed protein product
UniProt ID (Mouse) P21981