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Mouse TGM2 ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of mouse Transglutaminase 2/TGM2 in cell culture supernatants, plasma, and serum samples.
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : G[a]h, TG2, TGase2, Tgm2, tTG, tTGas
基因ID : (Mouse) 21817
基因符号 : Tgm2
蛋白别名 : C polypeptide, G alpha h, G-ALPHA-h, GNAH, RP5-1054A22.2, TGase-H, Tissue type transglutaminase, Transglutaminase 2 C polypeptide, Isopeptidase TGM2, Protein-glutamine deamidase TGM2, Protein-glutamine dopaminyltransferase TGM2, Protein-glutamine gamma-glutamyltransferase 2, Protein-glutamine histaminyltransferase TGM2, Protein-glutamine noradrenalinyltransferase TGM2, Protein-glutamine serotonyltransferase TGM2, protein-glutamine-gamma-glutamyltransferase, TG C, TG(C), TG2, TGase C, TGase II, TGase-2, TGC, Tissue transglutaminase, transglutaminase C, Transglutaminase II, Transglutaminase-2, tTG
UniProt ID (Mouse) P21981