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The Mouse Tn-I (Troponin I) ELISA quantitates Tn-I in serum, plasma, and other biological fluids
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : 2700018B22Rik, AI747285, cTnI, ssTnI, Tn1, Tnni1, Tnni3
基因ID : (Mouse) 21952, (Mouse) 21954
基因符号 : Tnni1, Tnni3
蛋白别名 : Cardiac troponin I, DKFZp451O223, Tpn1, Troponin I, cardiac muscle, slow skeletal muscle, slow-twitch isoform
UniProt ID (Mouse) Q9WUZ5, (Mouse) P48787