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Rat 4-1BB/TNFRSF9/CD137 quantitates rat 4-1BB/TNFRSF9/CD137 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat 4-1BB/TNFRSF9/CD137.
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
基因别名 : 4-1BB
基因ID : (Rat) 500590
基因符号 : Tnfrsf9
蛋白别名 : 4 1 BB, 41BB, s4 1 BB, s4 1BB, s41BB, sCD137, soluble 4 1 BB, soluble 4 1BB, soluble 41BB, soluble CD137, tumor necrosis factor receptor superfamily, member 9