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Rat IL-23 quantitates rat IL-23 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat IL-23.
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : Il23a
基因ID : (Rat) 155140
基因符号 : Il23a
蛋白别名 : il 23, IL 23 A, IL12B, Il-12b, Il12p40, Il-12p40, RP23-388G23.1, il23, ILN, Interleukin, interleukin 12B, MGC79388, p40, IL-23 subunit alpha, IL-23-A, IL-23p19, Interleukin-23 subunit alpha, Interleukin-23 subunit p19
UniProt ID (Rat) Q91Z84