靶标信息
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
同义词
4933415L04; acrosomal serine protease inhibitor; alpha-1 antiproteinase; antitr; antitrypsin; LOC480424; LOC483954; PAI3; PAI-3; Pci; PCI-B; PLANH3; Plasma serine protease inhibitor; plasminogen activator inhibitor 3; plasminogen activator inhibitor III; plasminogen activator inhibitor-3; PROCI; Protein C inhibitor; serine (or cysteine) peptidase inhibitor, clade A, member 5; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; serine (or cysteine) proteinase inhibitor, clade A, member 5; serpin A5; serpin B3; serpin family A member 5; serpin family B member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; serpin peptidase inhibitor, clade A, member 5; serpin peptidase inhibitor, clade B (ovalbumin), member 4; SERPINA5; SERPINB3; SERPINB4